Glioblastoma Activity is Altered by Hypoxia
Pathophysiologic oxygen induces morphological changes, increased expression of anti-apoptotic and proliferation markers, and miRNA expression dysregulation in GBM cells.
Nature BME Publishes Urgent Call for Reproducibility
A landmark article by Klein et al. calls for widespread change in environmental control in mammalian cell culture.
Metabolic Profile of Circulating ILC2s Depends on OXPHOS/O2
Surace et al. demonstrate complete control of O2 and physiologic parameters as they expand current knowledge of ILC2 metabolism in this notable publication in Nature Immunology.
Closed Manufacturing Platforms are Crucial for Cell Therapy Revolution
Abraham et al. assert that the next step towards commercial-scale autologous cell therapy manufacturing is closed, automated, and scalable platforms.
A Cytocentric Giant: Hal Broxmeyer
In December, we lost a mighty scientist who founded modern cord blood medicine, and showed the whole world how constant physiologic oxygen is critical to cells during isolation.
Oxygen Intrinsically Linked to Cell Senescence
Wiley and Campisi delve into the myriad causes of cellular senescence, including the influence of oxygen on senescent cell phenotype and frequency.