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Hypoxia in the Tumor Microenvironment Changes Drug Resistance

The right environment for studying drug effects on cells needs to include physiological oxygen levels, reports Chen et al.

Read more (open access): https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09520-5

 

The Transition from Low O2 to High O2 at Birth

Infant pulmonary artery smooth muscle cells undergo a change in potassium current after birth, report Nagaraj et al.

Read more (open access): https://www.mdpi.com/1422-0067/23/9/4681

 

New Treatments for Diabetes

Fernandez et al. detail how progress toward pancreatic beta cell transplantation includes adequate blood circulation for islets

Read more (open access): https://www.frontiersin.org/articles/10.3389/fbioe.2022.884071/

 

Oxygen: Too Much of a Good Thing?

Mancardi et al. describe the delicate balance between too much and too little O2 for cells

Read more: https://pubmed.ncbi.nlm.nih.gov/35412859/

 

O2 Affects Every Part of the Cell

A recent paper by Ferreri et al. details how oxygen affects the cell membrane lipidome.

Read more: https://pubmed.ncbi.nlm.nih.gov/35455966/

 

Klein Interview

The Visionaries Behind Three Landmark Reproducibility Papers

Prof. Mo Li, Dr. Shannon Klein, and Samhan Alsolami join us to talk about reproducibility, cell culture conditions, and reporting.

Find the full interview: https://biospherix.com/video

 

Hypoxic Liver Tumor Microenvironment Helps Maintain Cancer Stem Cells

Liang et al. introduce new ideas on how to tackle deadly liver tumors.

Read more: https://www.nature.com/articles/s41419-022-04848-z

 

Oxygen Used to Reprogram Bone Progenitors

The potency of skeletal progenitor cells was enhanced when Adipose-derived Mesenchymal Stromal Cells were cultured under hypoxia, Hosni et al. report.

Read more: https://www.cell.com/iscience/fulltext/S2589-0042(22)00329-7

 

Improving Therapeutic Efficacy of MSCs with Physioxia

Li et al. discuss the potential use of low oxygen to pre-activate therapeutic MSCs.

Read more: https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-02822-2

 

Severe COVID and the Proteasome

Alfaro et al. uncover a potential link between proteasome gene expression and COVID-19 complications.

Read more: https://www.mdpi.com/2218-273X/12/3/442

 

Avoiding EPHOSS by Controlling Oxygen for Hematopoietic Cells

Broxmeyer et al. collect, process, and compare bone marrow cells under hypoxia to demonstrate the differentiation fate determinancy of CaMKK2.

Read more: https://link.springer.com/article/10.1007/s12015-021-10306-8