Establishment of an iPSC-based Preeclampsia Model with Trophoblasts and Hypoxia for Understanding Placental Dysfunction In Vitro
Congratulations to first author Mariko Horii and team at University of California San Diego on their work which was first published March 15 in Scientific Reports evidencing the utility of an in vitro model with iPSC-derived trophoblasts which were subjected to hypoxia (2% O2) for gaining human-relevant insight about preeclampsia and other placenta-based disorders during pregnancy.
Click here to access the journal article (open access): https://www.nature.com/articles/s41598-021-85230-5
Researchers Establish an In Vitro Model for Assessing Y90 Radiotherapy Effectiveness in Colon Cancer Cells at Tumor Relevant Oxygen Levels
Congratulations to first author Piotr Piasecki and colleagues at Military Institute of Medicine, Warsaw on their February 24 publication in Scientific Reports which demonstrated a cell-based model for evaluating anticancer activity by Yttrium-90 microspheres in colorectal cancer. Unlike most cell culture studies which occur at room air oxygen (21% O2), the team assessed antitumor activity at both physioxic (5% O2) and hypoxic (1% O2) conditions that replicate actual levels measured in solid tumors.
Click here to access the journal article (open access): https://www.nature.com/articles/s41598-021-84000-7
ITPP Attenuates Tumor Hypoxia In Vitro through Regulation of Angiogenesis and Enhances Anticancer Immunoresponse
Congratulations to lead author Bouchra El Hafny-Rahbi and colleagues from UPR 4301, Center for Molecular Biophysics, CNRS – Orleans on their findings first published online February 23rd in Journal of Cellular and Molecular Medicine which demonstrated in vitro that myo-inositol-trispyrophosphate (ITPP) modulates angiogenesis to reduce hypoxia in the cancer microenvironment and promote the antitumor immune response.
Click here to access the journal article (open access): https://onlinelibrary.wiley.com/doi/10.1111/jcmm.16399
Hypoxia Combined with Dynamic Compression In Vitro Promotes Matrix-Forming Phenotype in Meniscus Fibrochondrocytes
Congratulations to lead author Alexander Szojka and colleagues from University of Alberta on their findings first published February 6th in Journal of Tissue Engineering which demonstrated that combining physiologic oxygen and dynamic compression with fibrochondrocytes in vitro promotes phenotypic properties which are favorable for human engineered meniscus.
Click here to access the journal article (open access): https://journals.sagepub.com/doi/full/10.1177/2041731421990842
BioSpherix exceeds 3000 Customer Publications!
Click here to access the article: http://biospherix.com/pdf/Dec2020_Customer_Journal_Articles.pdf
Physiologically Relevant Oxygen In Vitro Unlocks New Understanding in Placental Research
Our thanks to Cytocentric Visionary – Dr. Sandeep Raha from McMaster University for sharing insight about the use of physiologic oxygen in a cell-based model of the maternal-fetal interface to enhance both the in vivo relevance and reproducibility of in vitro experiments.
Click here to watch the Interview : https://www.youtube.com/watch?v=1Z6FBeGZzGQ
Increased Penetration of Gold Nanoparticles in a Spheroid Blood-Brain Barrier Model following Hypoxic Exposure
Congratulations to lead author Viktoriya Sokolova and colleagues from University of Duisburg-Essen and Wake Forest School of Medicine on their findings published October 22nd in Scientific Reports demonstrating that ultrasmall gold nanoparticles can cross the blood-brain barrier and also that spheroid exposure to hypoxic levels increases BBB permeability and enhances nanoparticle penetration.
Click here to access the journal article (open access): https://www.nature.com/articles/s41598-020-75125-2
Stem Cell Webinar Oct 28th with PHI, SBI, and BioSpherix: Relevant Conditions. Relevant Answers.
Click here to register – https://attendee.gotowebinar.com/register/1647376692062490640?source=BioSpherix+website
Physiologic Oxygen Enhances the Neuroprotective Effect of Human MSCs
Congratulations to lead author Wioletta Lech and her colleagues from Mossakowski Medical Research Centre on their findings published October 9th in Scientific Reports which establish the significant effect physiological oxygen levels have upon the neuroprotective potential of human mesenchymal stem cells.
Click here to access the journal article (open access): https://www.nature.com/articles/s41598-020-74066-0
– Cancer Research Webinar with PHI, SBI, and BioSpherix. Recording is Available Soon –
If you missed our 1st webinar ‘RELEVANT CONDITIONS. RELEVANT ANSWERS. The Secrets to Truly Controlled Cell Experiments for Cancer Research’ it will be available shortly for viewing on demand. Register to receive the recording – https://attendee.gotowebinar.com/register/3391558374569243150?source=BioSpherix+website