I-Glove

The I-Glove chamber integrates your existing cell incubator into a controlled workspace, simultaneously mitigating contamination, and exposure risk seen in traditional cell processing environments.

Configurations:

Right or left entry
Double-sided glovefront
O2/CO2 control in buffer chamber
O2/CO2 control in glove chamber
Continuous Recirculating Air Cleaner (CRAC)

Compatible with:

C-Chambers
ProCO2 120 Series
ProOx 360 Series

Cite this product: I-Glove Incubator Glove Box (BioSpherix, Ltd., RRID: SCR_021083)

ProCO₂ 120

The ProCO₂ 120 is a versatile and compact CO₂ controller designed for precise control in CO₂-sensitive environments.
It operates within limits of 0.1% to 20.0% CO₂, suitable for in vivo or in vitro physiologic conditions.

Specifications:

Electrical Power: 12 VDC at 2.5A
Control Range: 0.1-20% (±0.3%-0.7%) CO₂
Gas Supply: pressurized CO₂ or N₂
Gas Infusion Rate: 0-25 S.C.F.H.
Dimensions: 1.5”H x 3.5”W x 7”D
Compatible with most semi-sealed enclosures and equipment

Cite this product: ProCO2 120 Compact CO2 Controller (BioSpherix, Ltd., RRID: SCR_021127)

C-Shuttle

The BioSpherix C-Shuttle acts as a transport vessel between the glove box and incubator, ensuring continuous controlled conditions, such as O₂ and/or CO₂, for cells during transfer and manipulation. It is compatible with BioSpherix controllers and C-Chambers.

Configurations:

Right or left entry
O2/CO2 control in buffer chamber
O2/CO2 control in glove chamber
Continuous Recirculating Air Cleaner (CRAC)

Compatible with:

C-Chambers
ProCO2 120 Series
ProOx 360 Series

Cite this product: C-Shuttle Glove Box (BioSpherix, Ltd., RRID: SCR_021082)

The C-Chamber

Designed to fit inside an existing cell incubator, the C-Chamber provides a sub-chamber environment that protects cells from exposure to room air and other disturbances. C-Chambers can also be used to easily transport cells while maintaining desired environmental conditions. Multiple sizes are available to suit various pipelines and workflows.

Compatible with:

ProOx 110 Series
ProCO2 120 Series
OxyCycler C42
ProOx C21
C-Shuttle
I-Glove
Most 3rd party incubators

Size Options:

• One Shelf

• Two Shelf

• Three Shelf

• Four Shelf

Cite this product: C-Chamber Incubator Subchamber from BioSpherix Ltd, RRID: SCR_018189

OxyCycler A84XOV

The OxyCycler A84XOV is a versatile tool designed for precise control of oxygen levels, accommodating profiles from 0.1-99.9% oxygen with adjustable rates and durations. It is compatible with a wide range of chambers, including BioSpherix A-Chambers, and can manage up to four chambers simultaneously, offering independent or synchronized control. The system operates efficiently by using feedback from an oxygen sensor to regulate gas infusion, ensuring minimal waste and easy, automatic operation once set up.

Specifications

Electrical Power: 12 VDC @ 6.66A
Control Range: 0.1-99.9% (±1-2%) O₂
Gas Supply: N₂, O₂
Gas Infusion Rate: 1-150 S.C.F.H.
Dimensions: 9”H x 21.2”W x 18.5”D, 31lbs

Cite this product: OxyCycler A84XOV Dynamic O2 Animal Chamber Controller (BioSpherix, Ltd., RRID: SCR_021185)

OxyStreamer

The OxyStreamer controller for live cell microscopy offers dual streams of customizable oxygen and carbon dioxide gases without premixed cylinders. It independently monitors and blends gases (including nitrogen) to achieve precise O₂ (0.1-99.9%) and CO₂ (0.1-20.0%) concentrations in real time. Designed for ease of use, it maintains gas concentrations within 0.2% of setpoint levels through closed-loop control. Each stream’s flow rate is separately managed for efficient gas delivery to cell culture chambers and diffusion into media or perfusate, optimizing both gas and liquid phases simultaneously.

Specifications:

Electrical Power: 12VDC, 6.6AMP
Control Range: 0.1-99.9% ( ±1-2%) O₂, 0.1% to 20.0% (±1-2%) CO₂
Dimensions: 13.0”L x 9.3”W x 14.2”H, 10lbs

Cite this product: OxyStreamer O2 and CO2 Live Cell Microscopy Controller (BioSpherix, Ltd., RRID: SCR_021176)

OxyCycler AT Series

The OxyCycler AT Series supports simultaneous, independent gas control in two chambers at once, allowing for varied gas percentages or identical conditions at different times. Units can accommodate a wide range of gases including O₂, CO₂, CO, and NO, either individually or in combinations tailored to specific research needs. Dynamic programming of gas concentrations enables changes at various times and setpoints, supporting simulations of natural and artificial conditions.

Specifications:

Models: AT42CO, AT42N, AT82NN
Electrical Power: 12 VDC at 6.66A
Control Range: CO: < 1000 PPM, NO: < 300 PPM
Gas Supply: Pressurized CO, CO SPAN mix. Appropriate CO volume and concentration to be determined by lab safety officer.
Gas Infusion Rate: 1-25 S.C.F.H
Weight (Controller): 25lbs
Dimensions (Controller): 9”H, 21.25”W, 19”D

Cite this product:

OxyCycler AT42CO Carbon Monoxide Animal Chamber Controller (BioSpherix, Ltd., RRID: SCR_021186)
OxyCycler AT42N Nitric Oxide Animal Chamber Controller (BioSpherix, Ltd., RRID: SCR_021187)
OxyCycler AT82NN Nitric Oxide Animal Chamber Controller with NO2 Limit Control (BioSpherix, Ltd., RRID: SCR_021188)

OxyCycler A42OC

The OxyCycler A42OC is a versatile multi-chamber controller designed for precise O₂ and CO₂ management in animal modeling. It enables simultaneous, independent control of multiple chambers with different gas percentages or identical conditions at different times. Efficient gas control is ensured with feedback from adapter pod sensors, minimizing wastage and facilitating rapid recovery.

Specifications:

Electrical Power: 12 VDC @ 6.66A
Control Range: 0.1-99.9% (±1-2%) O₂, 0.1-20.0% CO₂
Gas Supply: N₂, O₂, CO₂
Gas Infusion Rate: 1-150 S.C.F.H.
Dimensions: 9”H x 21”W x 18.5”D, 22lbs

Cite this product: OxyCycler A42OC Dynamic O2 & CO2 Animal Chamber Controller (BioSpherix, Ltd., RRID: SCR_021183)

OxyCycler A41OV

The OxyCycler A41OV is a powerful tool designed for oxygen-sensitive research, enabling easy control of complex oxygen profiles. It offers full range control from 0.1% to 99.9% oxygen, with dynamic programming capabilities for fluctuating oxygen levels. Compatible with BioSpherix A-Chambers and adaptable to various enclosures, it installs quickly and operates autonomously once configured.

Specifications:

Electrical Power: 12 VDC @ 6.66A
Control Range: 0.1-99.9% (±1-2%) O₂
Gas Supply: N₂, O₂
Gas Infusion Rate: 1-150 S.C.F.H.
Dimensions: 9″H x 17″W x 14.5″D, 27lbs

Cite this product: OxyCycler A41OV Dynamic O2 Animal Chamber Controller (BioSpherix, Ltd., RRID: SCR_021182)

OxyCycler C42

The OxyCycler C42 is a dual gas controller that offers precise control over oxygen and carbon dioxide levels through independently programmable channels. It enables sophisticated oxygen profiles, crucial for simulating dynamic physiological conditions like hypoxia and hyperoxia. It includes computer software for easy operation, real-time trend charting, and data logging, ensuring precise experimental replication in normobaric conditions using semi-sealed subchambers.

Specifications:

Electrical Power: 12VDC, 6.6AMP
Control Range: 0.1-99.9% ( ±1-2%) O₂, 0.1-20% (±0.1-5%) CO₂
Gas Supply: Pressurized O₂, CO₂, N₂
Gas Infusion Rate: 0-12 S.C.F.H.
Weight (controller): 22lbs
Dimensions (controller): 9”H, 17”W, 16”D
Actuator Pod Dimensions: 4.4”H, 7.1”W, 3.75”D

Cite this product: OxyCycler C42 Dynamic O2 and CO2 Subchamber Controller (BioSpherix, Ltd., RRID: SCR_021109)

ProOx 110

The ProOx 110 is a reliable tool for oxygen-sensitive work, with full range control from 0.1% to 99.9% oxygen. It adjusts levels by infusing nitrogen to lower or oxygen to raise concentrations within any semi-sealable enclosure. Efficient operation is ensured with precise feedback from sensors, minimizing gas wastage.

Specifications:

Electrical Power: 12 VDC/2.5A
Control Range: 0.1-99.9% ( ±1-2%) O₂
Gas Infusion Rate: 1-35 S.C.F.H.
Dimensions: 1.5”H x 3.75”W x 7”D (Controller)
Compatible with most semi-sealed enclosures and equipment

Cite this product: ProOx 110 Compact O2 Controller (BioSpherix, Ltd., RRID: SCR_021129)

ProCO₂ 120ppm

The ProCO₂ 120ppm is a versatile parts-per-million limit controller designed to monitor and display gas levels within most semi-sealable enclosures. It remotely senses CO₂ levels and uses compressed dry air to influx sterile gases without introduction of contaminants.

Specifications:

Electrical Power: 12 VDC at 2.5A.
Control Range: 10 to 10,000ppm ±150ppm (@0ppm) to ±350ppm (@1000ppm) @25C and 1013hPa
Gas Supply: compressed dry air (CDA)
Gas Infusion Rate: 0-25 S.C.F.H.
Dimensions: 1.5”H x 3.5”W x 7”D
Compatible with most semi-sealed enclosures and equipment

Cite this product: ProCO2 120ppm Animal Chamber Off-Gas Limit Controller (BioSpherix, Ltd., RRID:SCR_021205 )

ProOx 360

The ProOx P360 is our flagship oxygen control tool designed for sensitive in vivo and in vitro applications, offering precise control from 0.1% to 99.9% oxygen levels. It uses sterile tank gas raise to adjust levels efficiently, both minimizing waste and without introducing contaminants from room air.

Specifications:

Electrical Power: 12 VDC at 2.5A
Control Range: 0.1-99.9% (±1-2%) O₂
Gas Supply: pressurized O₂, N₂
Gas Infusion Rate: 1-140 S.C.F.H.
Dimensions (Controller): 2.5”H x 8”W x 7”D, 2.2lbs
Compatible with most semi-sealed enclosures

Cite this product: ProOx 360 High Infusion Rate O2 Controller (BioSpherix, Ltd., RRID: SCR_021130)

ProOx C21

The ProOx C21 efficiently controls both oxygen (O₂) and carbon dioxide (CO₂) in cell cultures, fitting most bench-top incubators and chambers including the BioSpherix C-Chamber. It simulates various O₂ environments, adjusts CO₂ for pH balance, and ensures minimal gas wastage with rapid recovery technology. Designed to reduce contamination risks, it features a remote gas pod with disposable barriers for sterile gas delivery.

Specifications:

Electrical Power: 12 VDC at 2.5A
Control Range: 0.1-99.9% (±1-2%) O₂, 0.1-20% (±0.1-5%) CO₂
Gas Supply: pressurized N₂, O₂, CO₂
Gas Infusion Rate: 1-14 S.C.F.H.
Dimensions (Controller): 2.5”H x 8”W x 7”D, 2.2lbs

Cite this product: ProOx C21 Oxygen and Carbon Dioxide Subchamber Controller (BioSpherix, Ltd., RRID: SCR_021131)

A-Chamber

The A-Chamber is designed to house animal cages and containers to ensure precise atmospheric conditions critical for both animal welfare and experimental accuracy. Ventilation is managed passively, utilizing a fan for air circulation and adjustable ventilation ports on the sides to regulate airflow and maintain optimal conditions.

Cite this product: A-Chamber Animal Cage Enclosure (BioSpherix, Ltd., RRID: SCR_021177)

OxyCycler GT Series

The OxyCycler GT Series provides precise and advanced oxygen and carbon dioxide range control with the added benefits of humidity control, as well as NO and CO gas options. It adapts to most enclosures and chambers using an advanced adapter plate with a versatile multipod sensor assembly. Several combinations are available to create CO and NO gasotransmitter culture systems.

Specifications:

Models: 41, 4181C (CO control), 4181N (NO control), 4181 CN (CO and NO control)
Electrical Power: 12 VDC at 6.66A
Accuracy: 0.1-99.9% (±1-2%) O₂, 0.1-20.0% CO₂
Gas Infusion Rate: 1-25 S.C.F.H

Cite this product:

OxyCycler GT41 Dynamic O2, CO2, and RH Subchamber Controller System (BioSpherix, RRID: SCR_021110)
Oxycycler GT4181C Dynamic O2, CO2, and Carbon Monoxide Subchamber Controller System (BioSpherix, Ltd., RRID:SCR_021111 )
Oxycycler GT4181N Dynamic O2, CO2, and Nitric Oxide Subchamber Controller System (BioSpherix, Ltd., RRID: SCR_021112)
OxyCycler GT4181CN Dynamic O2, CO2, Carbon Monoxide, and Nitric Oxide Subchamber Cell Culture System (BioSpherix, Ltd., RRID: SCR_021113)

“ASEPTIC CELL PROCESSING AND PRODUCTION WITH NO CHEMICAL BIOCIDES” technology and systems is protected by US and international patents including:

United States patent US 11326140
Australia patent AU 2020370270 B2
China patent CN 114945658 B
Israel patent IL 292223
Japan patent JP 7409717
Republic of Korea patent KR 10-2596110
Mexico patent MX 400130

And also including patent pending in Canada, Brazil, European, Indonesia, India, Malaysia, New Zealand, Singapore, and Thailand.

“Cytocentric” is a registered trademark of BioSpherix, LLC, as well as the following non-exclusive list of terms:

CYTOCENTRIC CELL INCUBATION AND PROCESSING SYSTEMS
XVIVO SYSTEM
BIOSPHERIX
CYTOCENTRIC
XVIVO GMP SYSTEM

Please contact sales@biospherix.com for more details

Environmental Controllers

OxyCycler C42

OxyCycler GT Series

OxyStreamer

ProOx 110

ProOx 360

ProOx C21

ProCO₂ 120 ppm

ProCO₂ 120

OxyCycler A42OC

OxyCycler AT Series

OxyCycler A84XOV

OxyCycler A410V

ProCO₂ 120 ppm

ProCO₂ 120

ProOx 110

ProOx 360