Parish, NY, USA / Rockville, MD, USA, July 2025:
BioSpherix, LLC., a leader in closed-system cell culture and processing environments, and Cellbox Solutions Inc., a pioneer in portable CO₂ incubation technologies, are excited to announce a strategic partnership that will reshape the way living cells and tissue constructs are processed and delivered across research, clinical, and commercial applications.

This collaboration addresses a persistent challenge in the field of cell therapy and advanced biologics: the ability to maintain optimal, contamination-free conditions from cell processing through transport and final application. By integrating BioSpherix’s advanced Xvivo System®, a modular, closed-environment platform, with Cellbox™ portable CO₂ incubators, the two companies aim to create a fully controlled and connected workflow for living cells.

“Our partnership is built around a shared vision of protecting cell integrity at every stage,” said Syed Ahmed Mustafa, President of BioSpherix. “With Cellbox™ mobile incubator technology extending the reach of our Cytocentric® processing environments, we can now offer a seamless solution from culture to clinic. This is a critical step for any group working on sensitive, patient-specific therapies like Cells, tissues, or organoids.”

Cellbox™ incubators enable temperature and CO₂ control during transport, ensuring that cells remain in optimal conditions even while moving between facilities or clinical sites. By transferring cells directly from the BioSpherix closed systems into the Cellbox™, cell viability is ensured while regulatory and logistical risks are minimized.

“We are thrilled to join forces with BioSpherix, whose closed-system expertise is unmatched,” said Dr. Kathrin Adlkofer, Founder and CEO of Cellbox Solutions. “Together, we are addressing a major gap in the cell logistics pipeline by bridging the in-lab environment with what happens outside of it. The combination of our technologies not only improves reproducibility and sterility but also brings flexibility and scalability to the cell manufacturing process.”

The partnership will focus on co-developing application-specific workflows, particularly in the fields of cell and gene therapy, personalized medicine, and bioprinting. In addition, the companies plan to launch joint marketing and educational initiatives to promote best practices in end-to-end cell handling. The collaboration will further benefit from BioSpherix’s support for Cellbox™ logistics and technical service operations in the U.S., significantly reducing turnaround times for both routine and annual maintenance. This enhanced, U.S.-based technical infrastructure represents a valuable strategic asset for Cellbox™ and its partners. Moreover, the partnership strengthens and expands the reach of BioSpherix’s Cytocentric® mission, reinforcing its commitment to advancing cell-based care and innovation.

Key benefits of the partnership include:

• Local U.S.-based technical and logistical support for Cellbox™ products
  • Faster turnaround times for routine and annual maintenance
  • Reduced shipping delays through regional service infrastructure
• Joint application expertise for advanced cell and gene therapy workflows
• Extended reach and application of cell workflows globally

Key benefits of the integrated solution include:

• Seamless handoff from cell processing to mobile transport
• Enhanced compliance with Good Manufacturing Practice (GMP) standards
• Protection against contamination, temperature shock, and CO₂ fluctuations
• Improved reproducibility and cell viability for clinical outcomes
• Scalable solutions for decentralized manufacturing and delivery models

Both companies see this partnership as a significant milestone in accelerating the safe, effective deployment of cell-based products to patients around the world.

About BioSpherix LLC.
Based in Parish, New York, BioSpherix LLC. is the developer of the Xvivo System®, the world’s first and only fully modular and Cytocentric® cell culture system. The company is dedicated to advancing traditional cell processing through optimized, tightly controlled environments designed to enhance cell performance, and experimental integrity and reproducibility.

About Cellbox Solutions GmbH and Inc.
Headquartered in Hamburg, Germany, and a Subsidiary in Rockville, USA, Cellbox Solutions GmbH develops and manufactures the Cellbox™ – a portable CO₂ incubator designed for the safe transport of living cells, tissues, and other biological materials. The company supports research institutes, biotech firms, and pharmaceutical companies in closing the gap between laboratory and clinical applications.

For media inquiries, please contact:

For BioSpherix, LLC:

Dr. Madeline Keefe, mkeefe@bioSpherix.com

For Cellbox, Inc and Cellbox GmbH:

Jennifer Vosteen, vosteen@cellbox-solutions.com