Vascular ResearchVasBio 02

The 2019 Nobel Prize in Physiology or Medicine recognized scientific discovery of “how cells sense and adapt to oxygen availability”. In physiology, oxygen and other gaseous signaling molecules (CO2, NO, and CO) regulate vascular homeostasis by modulating:

  • vasodilation and vasoconstriction
  • vascular endothelial growth factor (VEGF) expression
  • angiogenesis and vasculogenesis
  • endothelial cell differentiation
  • vascular smooth muscle cell phenotype
  • cell-cell junction adhesion
  • reactive oxygen species (ROS) production

Vascular researchers control hypoxia, hyperoxia, physioxia, hypercapnia, nitric oxide, and carbon monoxide to carry out pathophysiological models (in vitro & in vivo) of: atherosclerosis, cardiac infarction, cerebrovascular disease, ischemia-reperfusion injury, oxidative stress, oxygen-induced retinopathy (OIR), pulmonary arterial hypertension (PAH), tumor angiogenesis, and wound ischemia.