Replicating sleep apnea research models with BioSpherix's cell equipment is more achievable due to the ability to control oxygen. Since sleep apnea is linked to a multitude of health complications, interest continues to grow in using cell-based models and animal models of:

  • obstructive sleep apnea (OSA)
  • central sleep apnea (CSA)
  • mixed sleep apnea
  • apnea of prematurity (AOP)
  • hypopnea

For in vivo models of sleep apnea, scientists use animal chambers capable of delivering oxygen exposures which alternate between normoxia (21% O2 in atmosphere) and hypoxia. For in vitro models, some sleep apnea protocols switch between room-air oxygen and hypoxia. Other cell-based models rapidly exchange between physiologic oxygen (physioxia) and pathological hypoxia to simulate apnea conditions. Some models (in vitro and in vivo) include control of elevated CO2 levels (hypercapnia) to replicate sleep apnea pathophysiology.

Flexible control options allow researchers to replicate existing models or develop new sleep apnea models. Scientists define hypoxia (and hypercapnia) profiles by selecting the following O2 values for experiments: peak, trough, ramp, soak, frequency, and duration. Use of multiple, independently-controlled chambers increases research throughput or permits different protocols to occur at the same time. Programmable clock and calendar function permits automated start/finish of experiments to ease staff scheduling.