Closed cell culture incubators
and hoods that simulate
physiologic oxygen

Closed cell culture incubators
and hoods that simulate
physiologic oxygen

STRUGGLING TO MAKE AN IMPACT WITH LIMITED TIME & MONEY?

Most labs aren’t equipped with incubators and hoods that simulate physioxic conditions. Cell culture in room air introduces artifact to cell assays. HIF modulation, cell metabolism, cell stress response, redox state, cell signaling, and gene expression are all changed.

Get the right equipment for controlling cell culture conditions that mimic the physoxic in vivo microenvironment.

Improve Research Relevance and Translatability

Options for Adding Physioxia/Physiologic Oxygen Controlled Cell Culture Capabilities

Upgrade your traditional CO2 incubator with physioxic chambers

BioSpherix

Replace your incubator and BSC with a closed cell incubation and handling chamber

BioSpherix

How do I get cytocentric equipment FOR SIMULATING OXYGEN LEVELS INSIDE THE BODY?

Step 1

TELL US ABOUT YOUR EXPERIMENT

Step 2

LET US HELP YOU REFINE OR REPLACE YOUR INCUBATOR WITH CYTOCENTRIC EQUIPMENT

Step 3

Get quality results

Search 3300+ customer research publications citing BioSpherix equipment

Visit a Cytocentric Lab

Physiologic Oxygen at University of Valencia

Physiologic Oxygen at University of Virginia

Physiologic Oxygen at Sanford Burnham Prebys Medical Discovery Institute

Physiologic Oxygen at SUNY Upstate Medical University

Physiologic Oxygen at RESTORE (Toulouse)

Videos

Interview with Cytocentric Visionary: Dr. Sandeep Raha from McMaster University – Physiologic O2 for In Vitro Placental Research Reveals New Understanding

LabRoots – Cell Biology Virtual Event 2018, “Fighting Against Air: Physiologic Oxygen and Reproducibility

BioSpherix – Avoid Irrelevant Non-Reproducible Data, The Neglected Variable: Physiologic Oxygen

Blog Posts

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CytoCentric Blog – What Oxygen Level Should I Use for My Cells In Vitro?

CytoCentric Blog – The Biology of HIF Proteins Impacts the Outcome of Your Experiments in Physiologic Oxygen

CytoCentric Blog – What Oxygen Level Does My Cell Culture Actually Experience?

CytoCentric Blog – Oxygen Terminology

Resources

Brochure – Tips for Planning, Executing and Reporting In Vitro studies at Physiologically Relevant Oxygen Levels

Publications

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Klein, S.G. et al. In situ monitoring reveals cellular environmental instabilities in human pluripotent stem cell culture. Commun Biol. 2022; 5, 119. doi:10.1038/s42003-022-03065-w

Dupont, M. et al. Autophagy Targeting and Hematological Mobilization in FLT3-ITD Acute Myeloid Leukemia Decrease Repopulating Capacity and Relapse by Inducing Apoptosis of Committed Leukemic Cells. Cancers (Basel). 2022;14(2):453. doi:10.3390/cancers14020453

Kumar, B. et al. Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity. Sci Adv. 2022;8(2):eabh3375. doi:10.1126/sciadv.abh3375

Herbemont, C. et al.Impact of oxygen tension according to embryo stage of development: a prospective randomized study. Sci Rep 11, 22313 (2021).

In the future, tears won’t accompany a diagnosis because

researchers will unlock the full potential of living cells to:

Reveal Truths

Discover Therapies

Heal Humans