Controlling Cell Phenotype in Tissue Constructs
Decellularized extracellular matrix scaffolds and hypoxic priming improves the phenotype of degenerate intervertebral disc cells, Penolazzi et al. report.
Read more: https://pubmed.ncbi.nlm.nih.gov/35537547/
Discovering New Treatment Modalities by Mimicking the TME
Qin et al. study androgen biosynthesis and hormone therapy resistance in prostate cancer.
Read more: https://pubmed.ncbi.nlm.nih.gov/35536859/
Culture Oxygen Drives MSC Metabolism
Olesen et al. discuss respiration and metabolic adaptation to low oxygen tension in mesenchymal stromal cells.
Read more (open access): https://www.sciencedirect.com/science/article/pii/S2589936822000056
Hypoxia in the Tumor Microenvironment Changes Drug Resistance
The right environment for studying drug effects on cells needs to include physiological oxygen levels, reports Chen et al.
Read more (open access): https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09520-5
The Transition from Low O2 to High O2 at Birth
Infant pulmonary artery smooth muscle cells undergo a change in potassium current after birth, report Nagaraj et al.
Read more (open access): https://www.mdpi.com/1422-0067/23/9/4681
New Treatments for Diabetes
Fernandez et al. detail how progress toward pancreatic beta cell transplantation includes adequate blood circulation for islets
Read more (open access): https://www.frontiersin.org/articles/10.3389/fbioe.2022.884071/
Oxygen: Too Much of a Good Thing?
Mancardi et al. describe the delicate balance between too much and too little O2 for cells
Read more: https://pubmed.ncbi.nlm.nih.gov/35412859/
O2 Affects Every Part of the Cell
A recent paper by Ferreri et al. details how oxygen affects the cell membrane lipidome.
Read more: https://pubmed.ncbi.nlm.nih.gov/35455966/
The Visionaries Behind Three Landmark Reproducibility Papers
Prof. Mo Li, Dr. Shannon Klein, and Samhan Alsolami join us to talk about reproducibility, cell culture conditions, and reporting.
Find the full interview: https://biospherix.com/video
Hypoxic Liver Tumor Microenvironment Helps Maintain Cancer Stem Cells
Liang et al. introduce new ideas on how to tackle deadly liver tumors.
Oxygen Used to Reprogram Bone Progenitors
The potency of skeletal progenitor cells was enhanced when Adipose-derived Mesenchymal Stromal Cells were cultured under hypoxia, Hosni et al. report.
Improving Therapeutic Efficacy of MSCs with Physioxia
Li et al. discuss the potential use of low oxygen to pre-activate therapeutic MSCs.
Severe COVID and the Proteasome
Alfaro et al. uncover a potential link between proteasome gene expression and COVID-19 complications.
Read more: https://www.mdpi.com/2218-273X/12/3/442
Avoiding EPHOSS by Controlling Oxygen for Hematopoietic Cells
Broxmeyer et al. collect, process, and compare bone marrow cells under hypoxia to demonstrate the differentiation fate determinancy of CaMKK2.
Enhanced Self-Renewal of HSC Under Physioxia
Physioxia induces downregulation of Tet2 in Hematopoietic Stem Cells, report Aljoufi et al.
Click here to read more (open access): https://ashpublications.org/blood/article/doi/10.1182/blood.2022015499/485747/Physioxia-induced-Downregulation-of-Tet2-in
Interview: Are We Missing the Best Anti-Cancer Drugs?
Professor Nakshatri joins Dr. Henn to discuss physioxia in tumor collection and culture for better drug development.
Click here to read more (open access): https://biospherix.com/video/
Peter Walters of CRB discusses how to prepare for commercial success, including enclosure at the earliest stages of process development.
Read more (open access): https://bioprocessintl.com/manufacturing/facility-design-engineering/scalability-in-cell-and-gene-therapy-manufacture-how-todays-developers-are-preparing-for-tomorrows-commercial-success/
Goldilocks, Radiation, and Cataracts in Space
Richard B. Richardson details the role of oxygen in cataract development in US astronauts.
B Cell Function, Development, and Metabolism are Regulated by HIF
A comprehensive review by Zhang et al. of immunoregulation by hypoxia and hypoxia-inducible factors.
Click here to read more (open access): https://www.frontiersin.org/articles/10.3389/fimmu.2022.967576/full
A Novel Photosynthetic Gel for Wound Healing
Developing novel treatments can require novel approaches, like that of Zhu et al., who mimicked peripheral artery disease in vitro to develop a novel topical gel to enhance localized hyperoxygenation.
Click here to read more (open access): https://www.nature.com/articles/s41598-022-14085-1
Hypoxia Improves MSC Therapeutic Potential
Silvestro et al. study congenital pulmonary airway malformations in infants and detail the role of hypoxia in therapeutic MSC applications.
Click here to read more (open access): https://pubmed.ncbi.nlm.nih.gov/35774062/
Mimicking the TME in Immunotherapy Studies
Ma et al. discuss drug resistance and epigenetic vulnerability in triple negative breast cancer.
Click here to read more: https://pubmed.ncbi.nlm.nih.gov/35840558/
Simulating Pathological Hypoxia to Study Neurodegeneration
Thinard et al. discuss a novel approach to therapy at the blood brain barrier.
Click here to read more (open access): https://www.mdpi.com/1999-4923/14/7/1418
Physioxia Diminishes Cellular Iron Dependency
New biosensors uncover altered cell metabolism in this study by Sevimli et al.
Click here to read more (open access): https://www.sciencedirect.com/science/article/pii/S221323172200091X