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Controlling Cell Phenotype in Tissue Constructs

Decellularized extracellular matrix scaffolds and hypoxic priming improves the phenotype of degenerate intervertebral disc cells, Penolazzi et al. report.

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Discovering New Treatment Modalities by Mimicking the TME

Qin et al. study androgen biosynthesis and hormone therapy resistance in prostate cancer.

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Culture Oxygen Drives MSC Metabolism

Olesen et al. discuss respiration and metabolic adaptation to low oxygen tension in mesenchymal stromal cells.

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Hypoxia in the Tumor Microenvironment Changes Drug Resistance

The right environment for studying drug effects on cells needs to include physiological oxygen levels, reports Chen et al.

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The Transition from Low O2 to High O2 at Birth

Infant pulmonary artery smooth muscle cells undergo a change in potassium current after birth, report Nagaraj et al.

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New Treatments for Diabetes

Fernandez et al. detail how progress toward pancreatic beta cell transplantation includes adequate blood circulation for islets

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Oxygen: Too Much of a Good Thing?

Mancardi et al. describe the delicate balance between too much and too little O2 for cells

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O2 Affects Every Part of the Cell

A recent paper by Ferreri et al. details how oxygen affects the cell membrane lipidome.

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Klein Interview

The Visionaries Behind Three Landmark Reproducibility Papers

Prof. Mo Li, Dr. Shannon Klein, and Samhan Alsolami join us to talk about reproducibility, cell culture conditions, and reporting.

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Hypoxic Liver Tumor Microenvironment Helps Maintain Cancer Stem Cells

Liang et al. introduce new ideas on how to tackle deadly liver tumors.

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Oxygen Used to Reprogram Bone Progenitors

The potency of skeletal progenitor cells was enhanced when Adipose-derived Mesenchymal Stromal Cells were cultured under hypoxia, Hosni et al. report.

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Improving Therapeutic Efficacy of MSCs with Physioxia

Li et al. discuss the potential use of low oxygen to pre-activate therapeutic MSCs.

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Severe COVID and the Proteasome

Alfaro et al. uncover a potential link between proteasome gene expression and COVID-19 complications.

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Avoiding EPHOSS by Controlling Oxygen for Hematopoietic Cells

Broxmeyer et al. collect, process, and compare bone marrow cells under hypoxia to demonstrate the differentiation fate determinancy of CaMKK2.

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Phase Holographic Imaging (PHI) visits the Wake Forest Institute for Regenerative Medicine (WFIRM) to finalize an agreement concerning the automation of advanced quality control in large-scale biomanufacturing of regenerative therapies.


Testing Facility Called “Game Changer” in Regenerative Medicine. The RegeneratOR Test Bed is an exciting game changer. The testing facility, located in North Carolina, provides supportive technology at no cost allowing companies to test and prove their cell-based products at various stages of development.

Enhanced Self-Renewal of HSC Under Physioxia

Physioxia induces downregulation of Tet2 in Hematopoietic Stem Cells, report Aljoufi et al.

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Interview: Are We Missing the Best Anti-Cancer Drugs?

Professor Nakshatri joins Dr. Henn to discuss physioxia in tumor collection and culture for better drug development.

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Closed Systems are the Future of Scalable Cell and Gene Therapy

Peter Walters of CRB discusses how to prepare for commercial success, including enclosure at the earliest stages of process development.

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Goldilocks, Radiation, and Cataracts in Space

Richard B. Richardson details the role of oxygen in cataract development in US astronauts.

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B Cell Function, Development, and Metabolism are Regulated by HIF

A comprehensive review by Zhang et al. of immunoregulation by hypoxia and hypoxia-inducible factors.

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A Novel Photosynthetic Gel for Wound Healing

Developing novel treatments can require novel approaches, like that of Zhu et al., who mimicked peripheral artery disease in vitro to develop a novel topical gel to enhance localized hyperoxygenation.

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Hypoxia Improves MSC Therapeutic Potential

Silvestro et al. study congenital pulmonary airway malformations in infants and detail the role of hypoxia in therapeutic MSC applications.

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Mimicking the TME in Immunotherapy Studies

Ma et al. discuss drug resistance and epigenetic vulnerability in triple negative breast cancer.

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Simulating Pathological Hypoxia to Study Neurodegeneration

Thinard et al. discuss a novel approach to therapy at the blood brain barrier.

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Physioxia Diminishes Cellular Iron Dependency

New biosensors uncover altered cell metabolism in this study by Sevimli et al.

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