biospherix neuroscience in vitro in vivo gap

Oxygen is an important physiological parameter in healthy neural tissues. Levels range 1-6% O2 for neurons and glial cells. They never experience the 21% O2 (room air oxygen) used in most cell-based neuroscience studies. Since oxygen modulates neural cell function, use of physiologic oxygen (or physioxia) during in vitro experiments is helpful for adding physiological relevance.

Oxygen regulates:

Pathological oxygen levels (hypoxia or hyperoxia) are used for in vitro / in vivo modeling of neural diseases and disorders: Alzheimer's Disease, Attention Deficit Hyperactivity Disorder (ADHD), brain ischemia, stroke, Amyotrophic Lateral Sclerosis (ALS), ischemia-reperfusion, oxygen glucose deprivation (OGD), neurodegeneration, gliomas (including glioblastoma), neuroplasticity, hypoxic-ischemic brain injury, sleep apnea, and neurodevelopmental disorders. Elevated CO2 (hypercapnia) is used for modeling anxiety or panic disorders.