Programmed control of dynamic oxygen conditions permit a range of biological modeling possibilities. Chambers for in vitro and in vivo exposures permit highly reproducible experiments using intermittent hypoxia (IH), acute intermittent hypoxia (AIH), episodic hypoxia, and chronic intermittent hypoxia (CIH). These studies advance scientific understanding of human disease, disorders, and conditions like:
- respiratory drive
- obstructive sleep apnea (OSA)
- apnea of prematurity
- oxidative stress
- neurodegeneration (Alzheimer’s and Parkinson’s)
Therapeutic models of IH are aimed at increasing motor function following spinal cord injury (SCI) or promoting neurogenesis to offset cognitive decline.
OxyCycler C42 & C-Chamber
In cell culture models of intermittent hypoxia, the OxyCycler C42 & C-Chamber package adds individually programmed hypoxia profiles (O2 and CO2) to any existing CO2 incubator. Configure the OxyCycler C42 & C-Chamber with more than one incubator subchamber (up to 2) to carry out separate IH experiments at the same time.
Xvivo System Model X3
The Xvivo System Model X3 hypoxia workstation provides full-time control of hypoxia for in vitro IH studies. Configure the Xvivo System with multiple incubator chambers (up to 9) to carry out simultaneous but independent hypoxia profiles at the same time. Closed hypoxia hoods adjoin the incubator chambers permitting scientists to move cells in/out without disruption of hypoxic conditions.