Closed incubators
and hoods for physiologically
relevant in vitro toxicology

Most labs aren’t equipped with tools for controlling oxygen. Room air conditions add ROS artifact to cell-based toxicological assays. This reduces the predictive capacity of tox assays, wasting precious time and money. Cell-based NAMs need protection from room air to accurately assess human risk.

Bordt EA. The importance of controlling in vitro oxygen tension to accurately model in vivo neurophysiology. Neurotoxicology. 2018 May;66:213-220.

Coyle JP, et al. Reduced oxygen tension culturing conditionally alters toxicogenic response of differentiated H9c2 cardiomyoblasts to acrolein. Toxicol Mech Methods. 2018 Sep;28(7):488-498.

Nzou G, et al. Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling. Sci Rep. 2018 May 9;8(1):7413.

Cytocentric Blog – Interview with Cytocentric Visionary: Ian Mudway, Lecturer – Respiratory Toxicology Lung Biology Group , King’s College London

Part One: What Are the Fundamental Things That We Absolutely Have To Get Right?

Part Two: Taking a Career Risk for Better Cell Culture and Better Science

Part Three: We Will Know We Have Gotten Through When People Complain About the Difficulties of Publishing Data Generated under Atmospheric Oxygen