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Unlike any other cell type, immune cells traverse blood, lymph, and tissues, and so, they are uniquely exposed to all of the different oxygen levels in the body (physioxia).

Ischemic injury and tumors can produce oxygen levels that are particularly low (hypoxia). None of these in vivo environments compare to room air oxygen, which is where most immunological assays are performed. That is an essential disconnect between in vitro and in vivo Immunology, contributing to problems with Reproducibility and Translatability of findings.

Evidence is accumulating that oxygen and Reactive Oxygen Species (ROS) affect immune cell function in profound ways. Below are some ways our hypoxia & modular incubator chambers are used in immunology research:

It is possible to control in vitro environments to the proper oxygen level for culturing cells as well as handling cells.


Cell Equipment

ProOx C21 & C-Chamber

Cell Research – physioxia/hypoxia chamber with static control of O2 and CO2 ProOx C21 & C-Chamber

OxyCycler C42 & C-Chamber

Cell Research – physioxia/hypoxia chamber with dynamic control of O2 and CO2C42 & C-Chambers

Xvivo System

Cell Research – physioxia/hypoxia workstation, combined oxygen incubator and hood system, in vitro oxygen/hypoxia glove box, with independently programmable control of O2, CO2, and Temp in one (or more) modular incubator chamber and/or hood chambers – Xvivo System