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Development

  • simulate physiologic intrauterine O2 levels
  • simulate physiologic embryonic/fetal tissue O2 levels
  • reproducibly model developmental/gestational hypoxia
  • reproducibly perform trophoblast models of pre-eclampsia
  • reproducibly model placental/intrauterine hypoxia
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Cell Equipment

ProOx C21 & C-Chamber

Cell Research – physiologic oxygen chamber, hypoxia chamber with static control of O2 and CO2 – C21 & C-Chamber

Xvivo System

Cell Research – physiologic oxygen incubator and hood system, hypoxia workstation, hypoxia glove box with independently programmable control of O2, CO2, and Temperature in one (or more) modular incubator chamber(s) and/or cell handling chamber(s) – Xvivo System

Animal Equipment

ProOx 360 & A-Chamber

Animal Modeling – hypoxia chamber with static control of O2 – ProOx 360 & A-Chamber

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In the Field

Placental Research at Tufts Medical Center

Placental & Trophoblast Research at UC San Diego School of Medicine

Videos


Interview with Cytocentric Visionary: Dr. Sandeep Raha from McMaster University – Physiologic O2 for In Vitro Placental Research Reveals New Understanding

Publications

Zhao H, et al. The Impact of Hypoxia in Early Pregnancy on Placental Cells. International Journal of Molecular Sciences. 2021; 22(18):9675.

Wong, Michael K et al. – “Establishment of an in vitro placental barrier model cultured under physiologically relevant oxygen levels.” Molecular human reproduction vol. 26,5 (2020): 353-365. doi:10.1093/molehr/gaaa018