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Development

  • simulate physiologic intrauterine O2 levels
  • simulate physiologic embryonic/fetal tissue O2 levels
  • reproducibly model developmental/gestational hypoxia
  • reproducibly perform trophoblast models of pre-eclampsia
  • reproducibly model placental/intrauterine hypoxia
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Cell Equipment

ProOx C21 & C-Chamber

Cell Research – physiologic oxygen chamber, hypoxia chamber with static control of O2 and CO2 – C21 & C-Chamber

Xvivo System

Cell Research – physiologic oxygen incubator and hood system, hypoxia workstation, hypoxia glove box with independently programmable control of O2, CO2, and Temperature in one (or more) modular incubator chamber(s) and/or cell handling chamber(s) – Xvivo System

Animal Equipment

ProOx 360 & A-Chamber

Animal Modeling – hypoxia chamber with static control of O2 – ProOx 360 & A-Chamber

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In the Field

Placental Research at Tufts Medical Center

Placental & Trophoblast Research at UC San Diego School of Medicine

Videos


Interview with Cytocentric Visionary: Dr. Sandeep Raha from McMaster University – Physiologic O2 for In Vitro Placental Research Reveals New Understanding

Publications

Strutz J, et al. Transient Hyperglycemia and Hypoxia Induce Memory Effects in AngiomiR Expression Profiles of Feto-Placental Endothelial Cells. Int J Mol Sci. 2021;22(24):13378. doi:10.3390/ijms222413378

Herbemont, C. et al. – Impact of oxygen tension according to embryo stage of development: a prospective randomized study. Sci Rep 11, 22313 (2021).

Zhao H, et al. The Impact of Hypoxia in Early Pregnancy on Placental Cells. International Journal of Molecular Sciences. 2021; 22(18):9675.

Wong, Michael K et al. – “Establishment of an in vitro placental barrier model cultured under physiologically relevant oxygen levels.” Molecular human reproduction vol. 26,5 (2020): 353-365. doi:10.1093/molehr/gaaa018