Development
- simulate physiologic intrauterine O2 levels
- simulate physiologic embryonic/fetal tissue O2 levels
- reproducibly model developmental/gestational hypoxia
- reproducibly perform trophoblast models of pre-eclampsia
- reproducibly model placental/intrauterine hypoxia
Cell Equipment
ProOx C21 & C-Chamber
Cell Research – physiologic oxygen chamber, hypoxia chamber with static control of O2 and CO2 – C21 & C-Chamber
Xvivo System
Cell Research – physiologic oxygen incubator and hood system, hypoxia workstation, hypoxia glove box with independently programmable control of O2, CO2, and Temperature in one (or more) modular incubator chamber(s) and/or cell handling chamber(s) – Xvivo System
Animal Equipment
Discover More
In the Field
Placental Research at Tufts Medical Center
Placental & Trophoblast Research at UC San Diego School of Medicine
Videos
Interview with Cytocentric Visionary: Dr. Sandeep Raha from McMaster University – Physiologic O2 for In Vitro Placental Research Reveals New Understanding
Publications
Herbemont, C. et al. – Impact of oxygen tension according to embryo stage of development: a prospective randomized study. Sci Rep 11, 22313 (2021).
Zhao H, et al. The Impact of Hypoxia in Early Pregnancy on Placental Cells. International Journal of Molecular Sciences. 2021; 22(18):9675.
Wong, Michael K et al. – “Establishment of an in vitro placental barrier model cultured under physiologically relevant oxygen levels.” Molecular human reproduction vol. 26,5 (2020): 353-365. doi:10.1093/molehr/gaaa018