Why do we call conventional cell culture equipment People-Centric?
It seems to meet the needs of people, and has for many years.
Manufacturers of conventional incubators, hoods, glove boxes, etc. have done a good job making products that people like and buy. Most people perceive conventional laboratory appliances to be reliable, economical, good looking, convenient, and perfectly functional. For the most part, they are!
However, sometimes cells need more!
That's where we come in. Since 1976 we have been "souping up" conventional People-Centric equipment. Others soup up hot rods. We soup up laboratory appliances. We soup up incubators, glove boxes, hoods, flush boxes, etc. We got started upgrading our own equipment while working in a cell research lab.
First was a retrofit O2 controller for our CO2 incubator. We had heard bone marrow stem cells like ours grew better in a lower O2 tension (5%) than our CO2 incubator could provide (18-20%). It worked great. Colleagues started asking if we could make them one for their incubator. Turns out it fit and worked in any make and model. Soon word-of-mouth spread. Eventually requests were coming from cell scientists all over the world. Later, of course, incubator manufacturers would build the feature of O2 control into their incubators. But by then our little modular retrofitting O2 controller had successfully transformed hundreds of their CO2 incubators into O2/CO2 incubators with the O2 levels cells needed. Today thousands of CO2 incubators around the world have been upgraded. More are getting "souped up" with O2 control every day.
Next was a combined O2/CO2 controller to retrofit glove boxes. People were trying to handle and grow mammalian cells in anaerobic bacteria glove boxes. We transformed anaerobic bacteria glove chambers into incubators with gloves that could grow and handle mammalian cells. Again, word-of-mouth spread. Eventually requests were coming from cell scientists all over the world. Later, of course, bacteria glove box manufacturers would build the feature of O2/CO2 control into their glove boxes. But by then we had already transformed many bacteria glove boxes and still do today.
Then scientists started asking us to design and build all sorts of new and diverse custom upgrades. Our reputation, as specialists in souping up conventional equipment, led to many new abilities, for all sorts of new features. Curiously, and gratifyingly, many were well known scientists, top scientists. They came to us because they could not get what they needed from laboratory appliance manufacturers. They needed more than what conventional equipment could provide. Their cells needed more.
Over 20+ years we developed and delivered dozens and dozens of solutions. These all consisted of modular upgrade accessories and retrofits, for all sorts of makes and models of incubators, glove boxes, flush boxes, etc. In one way or another they all increase the functionality of basic laboratory appliances with advanced what-we-now-call Cytocentric® features. The result? No matter what equipment you may currently own, no matter what it might currently lack in functionality, you can now too meet the needs of your cells!
A few years ago, for the sake of cells, we decided to re-think and re-invent cell incubation and processing. It resulted in what most will agree is an exciting new alternative to conventional laboratory appliances, The Xvivo System®.
However, you can still provide for virtually any need your cells might have, by simply upgrading your existing People-Centric Equipment. Depending on what equipment that might be, select the corresponding icon to the right and learn about all your Cytocentric upgrade options.
Upgrade Your Incubators
CYTOCENTRIC SOLUTION #1
Change the ambient O2 level to a lower physiologic level. Simply insert and operate your incubator inside the I-Glove with physiologic O2 control. I-Glove is the first and only glove box designed for housing incubators. Retains entire volume of incubator. Additional advantage of hands-on uninterruptibility, low gas consumption, and contamination protection from closed system.
(CO2 incubator + I-Glove )
CYTOCENTRIC SOLUTION #2
Integrate your O2/CO2 or CO2 incubator into an Xvivo System® model X3 with physiologic O2 control. No change in O2/CO2 when open incubator door. Additional advantage of hands-on uninterruptibility, low gas consumption, contamination protection from closed, aseptic system, and full integration of any other incubation and processing procedures and any 3rd party equipment. Add controllers or upgrade to our high performance incubators for dynamic control during incubation. Add multiple incubation chambers to increase the number of different protocols.
(CO2 incubator inside Xvivo System model X3 module)
CYTOCENTRIC SOLUTION #3
Add SubChamber Culture System to incubator and shuttle closed chamber back and forth to C-Shuttle Glove Box without exposing to room air or technicians and hands-on uninterruptibility.
(Incubator + SubChamber + CShuttle )
CYTOCENTRIC SOLUTION #4
Directly add O2 control to the CO2 incubator. Upgrade CO2 incubator with ProOx modular O2 controller with a SubChamber Culture System that controls physiologic O2 inside, isolated from the rest of the incubator. Transforms it into O2/CO2 incubator with wider range of O2 control including deep hypoxia down to 0.1%, which most built in O2/CO2 incubators can't do. Add additional controllers and subchambers to increase the number of different protocols in one incubator. It is cost efficient because you don't have to buy a new incubator. Additional advantage of space efficiency, gas efficiency or low gas consumption, and hands-off uninterruptibility. Opening incubator door will not disturb physiologic O2 or hypoxic O2.
(CO2 incubator + ProOx 110 with C-Chamber)
If multiple different protocols are needed:
Add SubChamber Culture System accessory to your incubator and provide exactly the conditions each different culture requires. You can have as many different protocols as the number of SubChambers you can fit inside your incubator.
2 subchambers for 3 protocols
3 subchambers for 4 protocols
4 subchambers for 5 protocols
If Dynamic Control during Incubation is needed:
CYTOCENTRIC SOLUTION #1 - Directly add dynamic control to any existing incubator. Modular retrofitting O2 and/or CO2 controllers such as the OxyCycler can fit any make or model, thermal incubators, CO2 incubators, O2/CO2 incubators. Retains volume of incubator, no matter how large.
CYTOCENTRIC SOLUTION #2 - Add SubChamber Culture System with dynamic control. Space efficient and gas efficient. Appropriate for smaller cultures.