Cytocentric-Blog

cytocentric visionaries td p3Cytocentric Visionaries: Tim Downing, PhD

Part Three: How Does the Question You Are Asking Change, in the Physiological Context, if You Are Not Working In Vivo?

This post contains excerpts from an interview that Dr. Alicia Henn, Chief Scientific Officer of BioSpherix, conducted with Dr. Timothy Downing. Our conversation was edited for brevity and clarity.

In the last post, we talked with Dr. Downing about how difficult it is to control for all of the factors that change when cells are removed from the body. Today we discuss Dr. Tim Downing's cell-focused research career and his path to this point.

cytocentric visionaries td p2Cytocentric Visionaries: Tim Downing, PhD

Part Two: Physiologic Simulation: You Can Never Step in the Same River Twice

This post contains excerpts from an interview that Dr. Alicia Henn, Chief Scientific Officer of BioSpherix, conducted with Dr. Timothy Downing. Our conversation was edited for brevity and clarity.

In the last post, Dr. Downing introduced us to his work on the Epigenomics of Cell Reprogramming and talked about some technical limitations. Today we talk in more depth about controlling the microenvironment for in vitro cell research.

cytocentric visionaries td p1Cytocentric Visionaries: Tim Downing, PhD

Part One: Understanding the Effect of the In Vitro Microenvironment on the Epigenomics of Cell Reprogramming


This post is part of a three-part series from an interview that Dr. Alicia Henn, Chief Scientific Officer of BioSpherix, conducted with Dr. Timothy Downing. Finishing a post-doc at The Broad Institute of MIT and Harvard this year, Dr. Downing will soon be taking a post at UC Irvine and launching his own laboratory. Our conversation on his perspectives on the in vitro cell microenvironment was edited for brevity and clarity.

We met Dr. Downing at ISSCR 2015 and were impressed by his enthusiasm and his visionary work on the in vitro microenvironment. We invited him here to share his perspectives.

cytocentric visionaries rr 05Cytocentric Visionaries: Roger Rönn

Part Five: Unbroken Optimized Conditions for Hematopoietic Stem Cells.

This is a five-part series of blog posts containing excerpts from an interview that Dr. Alicia Henn, Chief Scientific Officer of BioSpherix, conducted with Roger Rönn, who is finishing his PhD at Lund University. Our conversation on working in optimized conditions for hematopoietic cells was edited for brevity and clarity.

In the last post, Part Four, Roger told us about the benefits of physiologic oxygen for HSC in vitro. Today, we discuss the practical aspects of carrying out such experiments.

cytocentric visionaries rr 04Cytocentric Visionaries: Roger Rönn

Part Four: Physiologic Simulation for Hematopoietic Stem Cells

This is a five-part series of blog posts containing excerpts from an interview that Dr. Alicia Henn, Chief Scientific Officer of BioSpherix, conducted with Roger Rönn, who is finishing his PhD at Lund University. Our conversation was edited for brevity and clarity.

In the last post, Roger told us about factors that might make researchers hesitate to control oxygen levels for their cells. Today, we discuss the importance of low oxygen levels for HSC cells.