Cytocentric-Blog

bp34 image001Temperature, CO2, and pH in Cell Culture Media

What Seems Best for Incubation is Not Always Best for Handling

Most, but not all, cell culture media contain carbonate-based buffers which work with elevated gaseous carbon dioxide levels in the incubator to stabilize cell culture pH (see figure).  Carbonate-based buffers are present in vivo and so seem like an obvious choice for physiologically relevant incubation conditions. However, carbonate-based buffers can create non-optimal conditions for cultures during cell culture handling outside of the incubator. The critical cell parameters of temperature and carbon dioxide levels can affect carbonate buffered cell media. Continue reading to learn about the importance of having a cell culture growth medium during incubation.

Top 5 Cytocentric Publications of 2015

Overall, 2015 was a big year for moving cytocentric research forward. Some publications have stood out from the rest as impactful. The authors of these papers not only used cytocentric principles in carrying out their experiments, but their findings and language help describe a new scientific era of more physiologically relevant in vitro cell systems. Check out our list below to discover the top 5 publications for cell-focused research in 2015.

cytocentric visionaries ry p4Cytocentric Visionaries: Randy Yerden, CEO BioSpherix

Part Four: A Trachea for Hannah

This post contains excerpts from an interview that Dr. Alicia Henn, Chief Scientific Officer of BioSpherix, conducted with Randy Yerden, Founder and CEO of BioSpherix.

In part three of our interview, we discussed how cytocentric principles benefit cell based assays. Today we talk about the incredible experience of participating in groundbreaking surgery to implant a stem-cell bearing manufactured trachea into a toddler. Continue reading to learn how GMP cell therapy for the artificial trachea was performed with our donated Xvivo systems.

cytocentric visionaries ry p3

Cytocentric Visionaries: Randy Yerden, CEO BioSpherix

Part Three: Seeing Cytocentric Principles in Action

This post contains excerpts from an interview that Dr. Alicia Henn, Chief Scientific Officer of BioSpherix, conducted with Randy Yerden, Founder and CEO of BioSpherix.

In the 2nd part of this interview, we talked about the potentially reducing animal testing with relevant cell based assays by applying cytocentric principles. Today we talk about seeing Cytocentric Principles in action in research. Continue reading to learn how cytocentric principles have benefited research with cell based assays.

cytocentric visionaries ry p2Cytocentric Visionaries: Randy Yerden, CEO BioSpherix

Part Two: Physiologically-Relevant Cell-Based Assays to Reduce Wasteful Animal Testing

This post contains excerpts from an interview that Dr. Alicia Henn, Chief Scientific Officer of BioSpherix, conducted with Randy Yerden, Founder and CEO of BioSpherix.

In Part One, we talked about how the Cytocentric Principles were formed from decades of insight from top scientists about the needs of cells. Today we talk about how the total quality concepts in the Cytocentric Principles can reduce animal testing through relevant cell-based assays.