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Hypoxia in the Tumor Microenvironment Changes Drug Resistance

The right environment for studying drug effects on cells needs to include physiological oxygen levels, reports Chen et al.

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The Transition from Low O2 to High O2 at Birth

Infant pulmonary artery smooth muscle cells undergo a change in potassium current after birth, report Nagaraj et al.

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New Treatments for Diabetes

Fernandez et al. detail how progress toward pancreatic beta cell transplantation includes adequate blood circulation for islets

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Oxygen: Too Much of a Good Thing?

Mancardi et al. describe the delicate balance between too much and too little O2 for cells

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O2 Affects Every Part of the Cell

A recent paper by Ferreri et al. details how oxygen affects the cell membrane lipidome.

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Klein Interview

The Visionaries Behind Three Landmark Reproducibility Papers

Prof. Mo Li, Dr. Shannon Klein, and Samhan Alsolami join us to talk about reproducibility, cell culture conditions, and reporting.

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Hypoxic Liver Tumor Microenvironment Helps Maintain Cancer Stem Cells

Liang et al. introduce new ideas on how to tackle deadly liver tumors.

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Oxygen Used to Reprogram Bone Progenitors

The potency of skeletal progenitor cells was enhanced when Adipose-derived Mesenchymal Stromal Cells were cultured under hypoxia, Hosni et al. report.

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Improving Therapeutic Efficacy of MSCs with Physioxia

Li et al. discuss the potential use of low oxygen to pre-activate therapeutic MSCs.

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Severe COVID and the Proteasome

Alfaro et al. uncover a potential link between proteasome gene expression and COVID-19 complications.

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Avoiding EPHOSS by Controlling Oxygen for Hematopoietic Cells

Broxmeyer et al. collect, process, and compare bone marrow cells under hypoxia to demonstrate the differentiation fate determinancy of CaMKK2.

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