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Our CSO, Alicia Henn, to Moderate Upcoming NIST Workshop on Measurement in Biofabrication

Biofabricated tissue-engineered constructs have the potential to transform personalized medicine. However, characterizing these constructs post-fabrication and throughout preclinical use remains challenging. We will hold a 1-day workshop on measurement needs for biofabricated constructs that contain cells, focusing on metrology for the structure of the constructs, cell viability in the constructs, and functional capacity of the constructs.

Click here to read more: https://www.nist.gov/news-events/events/2022/12/workshop-measurement-needs-biofabrication-tissue-engineered-medical

Enhancing Clinical Translation with Preclinical Physioxia

Professors Adebayo and Nakshatri review the effect of extraphysiological oxygen shock/stress on cancer cells, even when they are exposed to ambient air only briefly.

Click here to read more: https://pubmed.ncbi.nlm.nih.gov/36169928/

Hypoxia Enhances NMJ Formation

Reprogrammed myoblasts improve the formation of neuromuscular junctions in this pioneer study by Tolsma et al.

https://pubmed.ncbi.nlm.nih.gov/36208481/

Congratulations to Emma Warner a WFIRM 2022 Scholar, who presented her data at the BMES Annual Meeting.

Emma used the Xvivo System Model X2 in her work at the RegMed TestBed at WFIRM this past summer.

Click here to read more: https://www.pharmamirror.com/pharmaceutical-articles/testing-facility-regenerative-medicine/

Neuroinflammation Regulation Therapies Tested Using Hypoxia

Wang et al. recreate pathophysiological conditions to study neuroprotection after cardiac arrest-induced brain injury.

Click here to read more (open access): https://pubmed.ncbi.nlm.nih.gov/35921049/

Intestinal Wound Healing and HIF

Steiner et al. review the double-edged sword HIF presents over the course of the metabolic response to chronic intestinal inflammation.

Click here to read more (open access): https://pubmed.ncbi.nlm.nih.gov/35912990/

Identifying EV Uptake Signals in Aggressive Pancreatic Cancer

Nigri et al. mimic pathophysiologic conditions to identify a potential target for therapeutic intervention into aggressive pancreatic ductal carcinoma.

Click here to read more (open access): https://pubmed.ncbi.nlm.nih.gov/35917363/

Osteogenesis and HIF Signaling in the Clinic

An in-depth review of recent progress in HIF-regulated bone regeneration provides evidence for novel tissue repair strategies.

Click here to read more (open access): https://pubmed.ncbi.nlm.nih.gov/35913258/

Creating Relevant Trophoblast Pathophysiology in vitro

Cheng et al. control oxygen around primary human trophoblasts to study autophagy-lysosomal machinery in early-onset preeclampsia.

Click here to read more (open access): https://pubmed.ncbi.nlm.nih.gov/35628454/

Relevant miRNA Patterns Under Pathophysioxia

Majewska et al. study the role of PTEN in kidney cancer by mimicking the TME in vitro.

Click here to read more (open access): https://pubmed.ncbi.nlm.nih.gov/35625614/

Extracellular Vesicles Require Proper Conditions

Almeria et al. detail how MSC produce more heterogeneous EVs when the upstream culture conditions are uncontrolled.

Click here to read more (open access): https://pubmed.ncbi.nlm.nih.gov/35501833/

Improving Tox Assay Predictability with Physioxia

Human renal proximal tubular epithelial cells exhibit in vivo-like properties in co-culture under physioxia, Piossek et al. report.

read more: https://pubmed.ncbi.nlm.nih.gov/35533734/

Oxygen Controls the Lymphovascular-Immune Ensemble

Schito et al. review the role of hypoxia in the lymphatic system’s response to cancer.

read more: https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00095-4?

Physioxia Influences Gene Methylation

Dogan et al. use physiological oxygen to examine epigenetic modification in pluripotent stem cells.

Click here to read more (open access): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148100/

Altering O2 in Solid Tumor Studies

Herrera-Campos et al. review the role of hyperoxia and the immune system in novel treatments for solid tumors.

Click here to read more (open access): https://www.mdpi.com/2072-6694/14/11/2740/htm

Enhanced Self-Renewal of HSC Under Physioxia

Physioxia induces downregulation of Tet2 in Hematopoietic Stem Cells, report Aljoufi et al.

Click here to read more (open access): https://ashpublications.org/blood/article/doi/10.1182/blood.2022015499/485747/Physioxia-induced-Downregulation-of-Tet2-in

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Recent News

PHI, SAS, QIAGEN and BioSpherix form Alliance to Advance Cell-based Biomanufacturing

Phase Holographic Imaging (PHI) visits the Wake Forest Institute for Regenerative Medicine (WFIRM) to finalize an agreement concerning the automation of advanced quality control in large-scale biomanufacturing of regenerative therapies.

trending

Testing Facility Called “Game Changer” in Regenerative Medicine. The RegeneratOR Test Bed is an exciting game changer. The testing facility, located in North Carolina, provides supportive technology at no cost allowing companies to test and prove their cell-based products at various stages of development.

recent publications

Labuz, D. F., et al. Intrauterine Growth Restriction (IUGR) as a potential target for transamniotic stem cell therapy Journal of pediatric surgery. 2022; doi:10.1016/j.jpedsurg.2022.01.062

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Modeling Acute Kidney Injury

Kim et al. discover a recombinant protein cocktail that accelerates kidney repair after renal ischemia-reperfusion injury.
read more: https://www.frontiersin.org/articles/10.3389/fbioe.2022.848679/full

Regulators of Cholesterol Homeostasis in Human Placental Endothelium

Strahlhofer-Augsten et al. dive into the role of SR-BI in vasculature by mimicking the placental environment with physioxia.
read more: https://pubmed.ncbi.nlm.nih.gov/35628180/

Reproducing Ovarian Tumor Conditions in vitro

Strahlhofer-Augsten et al. dive into the role of SR-BI in vasculature by mimicking the placental environment with physioxia.
read more: https://www.nature.com/articles/s42003-022-03495-6

Oxygen Regulates Tumor Immune Escape

Wu et al. review the role of HIF in TME regulation.
read more: https://jhoonline.biomedcentral.com/articles/10.1186/s13045-022-01292-6

“Maintaining Physioxia in Cell Culture is Imperative”

Alva et al. review the current state of supraphysioxia in mammalian cell culture and call for better practices.
read more: https://www.mdpi.com/2073-4409/11/19/3123

Modeling OGD with a Controlled Environment

Calabrese et al. study resilience to neuronal ischemic injury by modeling oxygen glucose deprivation with an oxygen-controlled processing chamber.
read more: https://pubmed.ncbi.nlm.nih.gov/36229429/