Over 30 years ago, our founder pioneered the development of the first device capable of precisely controlling oxygen levels within an incubator. This simple but groundbreaking innovation exposed a critical flaw in traditional cell culture methods: existing systems failed to provide cells with physiologically relevant conditions. Recognizing this gap laid the foundation for the Cytocentric® platform—where systems are designed entirely around the needs of cells.

Addressing this unmet need led to the creation of the Xvivo System®: a modular, customizable, and portable aseptic environment that surrounds entire protocols in an optimally controlled atmosphere. With flexible design options and continuous, dynamic environmental control, the Xvivo System® easily adapts to the evolving needs of cell research and production pipelines.

The introduction of this technology has catalyzed transformative advancements in drug development, regenerative medicine, and cell therapies. For the first time, researchers and manufacturers are able to culture and process cells in a fully physiological environment—yielding dramatically improved reproducibility, functionality, and clinical potential.

Below is some of our data demonstrating why maintaining physiologic oxygen levels and comprehensive environmental control—hallmarks of our systems—produce superior results compared to conventional, ambient-air methods.
Through side-by-side comparisons, key performance metrics, and real-world examples, we highlight the profound impact that true physiological conditions have on cell health, behavior, and therapeutic efficacy. Our science shows that when cells are given what they truly need, the outcomes aren’t just better—they’re revolutionary.