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It’s All About the Cargo: O2 Levels Change Exosome Signaling

Jiang et al. summarize the cargo changes and biological effects of hypoxia on exosomes.

Regenerating Muscle Requires Physioxia

Elashry et al. find that exposure to low oxygen promotes the multipotency of skeletal muscle-derived stem cells, benefitting tissue regeneration.

Oxygen as a Signaling Molecule

Early erythroid cell fate is influenced by oxygen concentration, as shown by Labat et al. of Universite de Bordeaux.

Corneal Endothelial Cells Behave Differently at Physioxia

Patel et al. evaluate the metabolism of HCEnCs cultured at physiological O2 and room air.

Using the GBM Microenvironment to Regulate Plasticity

Uribe et al.’s review of glioblastomal adaptation details plasticity regulation in hypoxic niches.

Advancing Cell-Based Meniscal Therapies with the Use of Physioxia

Pattappa et al. present further evidence of the enhanced clonogenicity and differentiation potential of meniscus cells under physiologic O2.

Hypoxia Unmasks New Therapeutic Targets

Clees et al. detail how physiologic hypoxia alters the regulation of nine distinct proteins in multiple myeloma cells.

Landmark Paper Demonstrates Environmental Instability in Cell Culture

Another breakthrough paper from Klein et al. has demonstrated a pervasive issue affecting in vitro experimental findings: large fluctuations of environmental conditions during standard batch culture.

Modeling Preeclampsia with Oxygen In Vitro

Strutz et al. model fetal hypoxia and find memory effects on angiomiR expression in fpEC.

Culturing Under Hypoxia Reveals Prostate Cancer Growth Regulator

Rios-Colon, et al. of Wake Forest Baptist Medical Center demonstrate how Carnitine Palmitoyltransferase 1 regulates PCa survival and aggressiveness under hypoxic conditions.

Hypoxic Conditions Stabilize HIF-1a in Brain Endothelium

University of Copenhagen authors Ozgur et al. detail how hypoxia increases expression of some blood-brain barrier transporters in brain capillary endothelial monolayers

Culturing Under Physioxia Improves Human Embryo Quality and Development

Herbemont et al. find more evidence that encourages use of a physiologic O2 environment for human embryos at cleavage stage.

Guidance on Good Cell Culture Practices 2.0 is Now Available

The updated guidance document addresses quality management in a new age of research, providing insight into reproducible methods for in vitro cell culture.

Using Oxygen to Control Differentiation

A comprehensive review by Hu et al. highlights hypoxia as a tool for modulating chondrocyte redifferentiation.