Cytocentric Blog

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Cytocentric Visionaries: Dr. Heather O’Leary

Part One: Extraphysiologic Oxygen Shock

This is a three-part series of blog posts containing excerpts from an interview that Dr. Alicia Henn, Chief Scientific Officer of BioSpherix, conducted with Dr. Heather Ann O’Leary. Dr. O’Leary has finished up a post-doc in the laboratory of Hal Broxmeyer and is starting up her own lab at Indiana University. Her talk was a highlight of ISSCR 2015 where she reported on a landmark paper published in Cell. [1]  Our conversation was edited for length and clarity.

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“Standards” as a Dirty Word: The Fixable Problems behind the In Vitro Reproducibility Crisis

Leonard Freedman, President of the Global Biological Standards Institute in Washington, D.C. published a paper last year in PLOS Biology which it was calculated that $28 billion is wasted yearly on irreproducible pre-clinical research in the US. In our interview with Dr. Freedman, posted on LinkedIn, he says that while that number became a big focus in the press, that this paper also outlined very achievable fixes for some of the most pervasive problems behind the In Vitro Reproducibility Crisis.

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Cytocentric Visionaries: Ian Mudway, King's College, UK

Part Three: We Will Know We Have Gotten Through When People Complain About the Difficulties of Publishing Data Generated under Atmospheric Oxygen

 

In Part Two, Dr. Henn talked with Dr. Ian Mudway about difficulties in getting publishers and the greater scientific community to embrace his important findings. Here, they discuss overcoming scientific inertia and paradigm shift.

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Cytocentric Visionaries: Ian Mudway, King's College, UK

Part Two: Taking a Career Risk for Better Cell Culture and Better Science

 

In Part One, Dr. Henn talked with Dr. Ian Mudway about his recent publication , “Quantifying the magnitude of the oxygen artefact inherent in culturing airway cells under atmospheric oxygen versus physiological levels.”

Here, they discuss barriers to change in the scientific community.

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Cytocentric Visionaries: Ian Mudway, King's College, UK

Part One: What Are the Fundamental Things That We Absolutely Have To Get Right?

Alicia Henn, Chief Scientific Officer, BioSpherix

Ian Mudway is a Lecturer in Respiratory Toxicology at King’s College in London. He has been active in air pollution research, participating in Air Quality conferences, speaking out on BBC World News and in the Guardian newspaper, and advising the World Health Organization.

Here, Dr. Henn talks with Dr. Mudway about his recent publication , Quantifying the magnitude of the oxygen artefact inherent in culturing airway cells under atmospheric oxygen versus physiological levels.”

 

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