Cytocentric Blog

Are We Doing Enough to Protect Our People in the Lab?

 bp049 header

(image: Wikipedia)

Mysterious Illnesses

Two documented cases of laboratory-acquired infections (LAI) have made it into the popular media this year alone, one in Europe and one at the CDC. In both of these cases, workers doing routine work with standard procedures somehow became infected with biological materials they handled and nobody knows how.  

We would all like to think that LAI are quite rare, but they still happen, so the risk is still there for all laboratory workers, both in the clinical and the research setting.

Read more...

cv header HOLp3

Cytocentric Visionaries: Dr. Heather O’Leary

Part Three: Hypoxia, Metabolism, and Is Room Air “Good Enough” for Stem Cells?

This is final part in a three-part series of blog posts containing excerpts from an interview that Dr. Alicia Henn, Chief Scientific Officer of BioSpherix, conducted with Dr. Heather O’Leary.

In the last post, Dr. O’Leary talked with us about specific technical challenges in working with cells in low oxygen.  Here we talk about terminology for physiologically relevant oxygen studies and whether or not room air is “good enough.”

Read more...

cv header HOLp2

Cytocentric Visionaries: Dr. Heather O’Leary

Part Two: The Technical Challenges of Working in Physiologic Oxygen with Less-than-ideal Equipment

This is Part Two in a three-part series of blog posts from an interview that Dr. Alicia Henn, Chief Scientific Officer of BioSpherix, conducted with Dr. Heather O’Leary. Our conversation was edited for length and clarity.

In Part One, Heather told us about why her work is so exciting. Today, Heather talks with us about practical considerations that might limit researchers wanting to keep their cells in low-oxygen.

Read more...

cv header HOLp1

Cytocentric Visionaries: Dr. Heather O’Leary

Part One: Extraphysiologic Oxygen Shock

This is a three-part series of blog posts containing excerpts from an interview that Dr. Alicia Henn, Chief Scientific Officer of BioSpherix, conducted with Dr. Heather Ann O’Leary. Dr. O’Leary has finished up a post-doc in the laboratory of Hal Broxmeyer and is starting up her own lab at Indiana University. Her talk was a highlight of ISSCR 2015 where she reported on a landmark paper published in Cell. [1]  Our conversation was edited for length and clarity.

Read more...

“Standards” as a Dirty Word: The Fixable Problems behind the In Vitro Reproducibility Crisis

Leonard Freedman, President of the Global Biological Standards Institute in Washington, D.C. published a paper last year in PLOS Biology which it was calculated that $28 billion is wasted yearly on irreproducible pre-clinical research in the US. In our interview with Dr. Freedman, posted on LinkedIn, he says that while that number became a big focus in the press, that this paper also outlined very achievable fixes for some of the most pervasive problems behind the In Vitro Reproducibility Crisis.

Read more...