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Hypoxic Cell Culture Used to Identify Therapeutic Targets

By characterizing PASMCs cultured under hypoxia, He et al. examine the critical role vascular cell metabolism plays in hypoxic pulmonary hypertension.

Read more (open access): https://www.frontiersin.org/articles/10.3389/fphar.2021.753727/full

 

New Data Spotlights Need for Greater Rigor and Transparency

The long-awaited conclusion of the Reproducibility Project: Cancer Biology. Only 46% of reported effects could be replicated across 50 high-impact studies.

Read more: https://elifesciences.org/articles/71601

 

Glioblastoma Activity is Altered by Hypoxia

Pathophysiologic oxygen induces morphological changes, increased expression of anti-apoptotic and proliferation markers, and miRNA expression dysregulation in GBM cells.

Read more: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-021-08978-z

Nature BME Publishes Urgent Call for Reproducibility

A landmark article by Klein et al. calls for widespread change in environmental control in mammalian cell culture.

Read more: https://www.nature.com/articles/s41551-021-00775-0

Metabolic Profile of Circulating ILC2s Depends on OXPHOS/O2

Surace et al. demonstrate complete control of O2 and physiologic parameters as they expand current knowledge of ILC2 metabolism in this notable publication in Nature Immunology.

Read more: https://www.nature.com/articles/s41590-021-01043-8

Closed Manufacturing Platforms are Crucial for Cell Therapy Revolution

Abraham et al. assert that the next step towards commercial-scale autologous cell therapy manufacturing is closed, automated, and scalable platforms.

Read more: https://www.sciencedirect.com/science/article/abs/pii/S2468451121000805

A Cytocentric Giant: Hal Broxmeyer

In December, we lost a mighty scientist who founded modern cord blood medicine, and showed the whole world how constant physiologic oxygen is critical to cells during isolation.

Read More: https://biospherix.com/cytocentric-visionaries-hal-broxmeyer-2/

Oxygen Intrinsically Linked to Cell Senescence

Wiley and Campisi delve into the myriad causes of cellular senescence, including the influence of oxygen on senescent cell phenotype and frequency.

Read more: https://www.nature.com/articles/s42255-021-00483-8

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MSC Therapy is Improved by Physiologic O2

A comprehensive review by Egger et al. concludes that physiologic O2 levels maintain or increase the therapeutic properties of MSCs, and calls for reduced oxygen conditions during isolation and expansion of cells for cell products.

Read more (open access): https://onlinelibrary.wiley.com/doi/full/10.1002/elsc.202100097

Anticancer Drug More Potent at Physioxia

Otto-Ślusarczyk et al. of the Medical University of Warsaw find greater effectiveness of Teriflunomide at physiological oxygen levels, suggesting in vitro studies at room-air O2 could be underestimating drug potency.

Read more (open access): https://www.sciencedirect.com/science/article/pii/S2405580821002351?via%3Dihub

Physiologic Oxygen Decides Placental Development, Pregnancy Outcomes

A review of the critical role physioxia plays in development and maternal immunity during pregnancy, by Hui Zhao et al. of Stanford University School of Medicine.

Read more (open access): https://www.mdpi.com/1422-0067/22/18/9675

Hypoxia Induces Quiescence In Vitro in Treatment-Resistant Leukemic Cells

O’Reilly et al. of the Apoptosis Research Centre create models of quiescent leukemic stem cells by mimicking the bone marrow microenvironment, leading to a potential method of high-throughput drug screening.

Read more (open access): https://www.frontiersin.org/articles/10.3389/fcell.2021.662868/full

O2 Tension Alters Chemical Sensitivity in ESC Culture

RIVM’s Mennen et al. demonstrate the influence of oxygen level on the chemical sensitivity of the ESTc, a model for developmental toxicity predictions.

Read more:https://linkinghub.elsevier.com/retrieve/pii/S0887-2333(21)00172-7