ANIMAL MODELING

A Chamber 30 R 
Chronic exposures to hypoxia, hyperoxia, and hypercapnia can be simulated with ProOx/ProCO2 controllers
 OxyC and 4 A Chambers
Simultaneously simulate multiple dynamic O2/CO2/CO/NO exposures with our OxyCycler series of controllers

If you need to complement your in vitro work with in vivo data, or need certain animal models for therapeutic or disease modeling and pre-clinical data, explore our full line of animal equipment for in vivo modeling.
Equipment consists of various chambers designed to hold animal cages and various compatible controllers that generate appropriate physiologic or pathologic exposures inside the chambers to create the models.

Maximize Reproducibility in DISEASE MODELS:

• Ocular Angiogenesis – Abnormal blood vessel formation in the eye is a major cause of blindness. Conditioning newborn animals with various hyperoxic, hypercapnic exposures, creates rich retinal neovascularization when animals are returned to normal air, and that simulates to various degrees the abnormal blood vessel formation seen in Retinopathy of Prematurity, Diabetic Retinopathy, and Adult Macular Degeneration. These models are used widely to study angiogenesis.
Pulmonary Hypertension – Chronic hypoxia
Systemic Hypertension – Chronic intermittent hypoxia
Apnea– Acute hypoxia and/or hypercapnia
Sleep Apnea – Chronic periodic intermittent hypoxia and/or hypercapnia
Apnea of Prematurity – Chronic sporadic hypoxia and/or hypercapnia
SIDS (Sudden Infant Death Syndrome) – Progressive acute hypercapnia and hypoxia
Atherosclerosis – Chronic moderate intermittent hypoxia
Ischemia (Cardiac Infarction, Stroke, etc.) – Acute hypoxia usually in conjunction with surgical clamping of major artery.
COPD (Chronic Obstructive Pulmonary Disease) – Chronic ozone exposure followed by moderate progressive chronic hypoxia and/or hypercapnia.
Pulmonary Fibrosis – Chronic or intermittent ozone exposure.
ADHD (Attention Deficit Hyperactivity Disorder) – Maternal gestational intermittent hypoxia.
Polycythemia – Chronic hypoxia
Developmental Disabilities / Eclampsia – Newborn chronic deep hypoxia in conjunction with surgical ablation procedure
Recreational Hyperoxia (Oxygen Bars, athletic oxygen supplementation) – Acute hyperoxia
Recreational Hypoxia (Athletic conditioning) – Chronic periodic moderate hypoxia
Occupational Hypoxia / Altitude Sickness (airline, observatory astronomers, mining) – Chronic or periodic moderate hypoxia
Acute Mountain Sickness – Progressive graded hypoxia

OR THERAPEUTIC MODELS:

Traditional Respiratory Therapy – There's a growing recognition that traditional oxygen supplementation is a two edge sword; along with the immediate benefit there is a long term price to pay. High oxygen causes oxidative damage to cells lining the respiratory tract.
New Carbon Monoxide Therapy – Carbon monoxia and or hyperoxia or hypoxia and or hypercapnia
New Nitric Oxide Therapy
New Hypoxia Therapy


Animal Products

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A-Chamber

Animal Cage Enclosures

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OxyCycler A84XOV

Dynamic O2 Controller with Multiple Chambers

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OxyCycler A41OV

Dynamic O2 Controller

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ProOx 360

Static O2 Controller for Larger Volume

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ProOx 110

Static O2 Controller

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OxyCycler A44C

Dynamic CO2 Controller

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ProCO2 120

Static O2 Controller

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ProCO2 120ppm

Static CO2 ppm Controller

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OxyCycler A42OC

Dynamic O2/CO2 Controller

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OxyCycler AT42CO

Dynamic CO Controller

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OxyCycler AT42N

Dynamic NO Controller

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OxyCycler AT82NN

Dynamic NO/NO2 Controller

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Safety Hood

Hood for Animal Chambers